1969313-51-6
1969313-51-6
Chemical Structure
Onvatilimab
Synonym(s): JNJ-61610588; CI-8993; VSTB112
- CAS No.: 1969313-51-6
- Formula:N/A
- Molecular Weight:(144.52 kDa)
IUPAC Name: 5-chloro-N2-(3-(thiophen-3-yl)phenyl)-N4-(3-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine
SMILES: [Onvatilimab]
Biological Activity: Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research[1][2].
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Onvatilimab | 98.00% | Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research. | ||||||||||||||||||||
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References
- [1]. Katsiaryna Marhelava, et al. Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer. Cancers (Basel). 2019 Nov 8;11(11):1756. [Content Brief]
- [2]. Wu L, et al. METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancer. J Immunother Cancer. 2024 Dec 9;12(12):e009865. [Content Brief]
Keywords
