2002381-25-9
2002381-25-9
Chemical Structure
APS-2-79
- CAS No.: 2002381-25-9
- Formula:C23H21N3O3
- Molecular Weight:387.43
IUPAC Name: 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine
InChIKey: PEKZLFZZBGBOPJ-UHFFFAOYSA-N
SMILES: CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=NC=NC4=CC(OC)=C(OC)C=C43
Biological Activity: APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
APS-2-79 | 99.38% | APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
APS-2-79 (Standard) | ≥98% | APS-2-79 (Standard) is the analytical standard of APS-2-79 (HY-100627). This product is intended for research and analytical applications. APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
