2035018-15-4
Chemical Structure
MP-1
- CAS No.: 2035018-15-4
- Formula:C15H17NO3S
- Molecular Weight:291.37
IUPAC Name: (E)-3-(furan-2-yl)-N-(2-(5-(1-hydroxyethyl)thiophen-2-yl)ethyl)acrylamide
InChIKey: YZXWIWRFQLQZMF-QPJJXVBHSA-N
SMILES: O=C(NCCC1=CC=C(C(C)O)S1)/C=C/C2=CC=CO2
Biological Activity: MP-1 is a potent Fumarate hydratase-dependent hit. MP-1 engages an array of functional cysteines, including one lying in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. MP-1 causes fumarate hydratase-dependent synthetic lethality in a metastatic hereditary leiomyomatosis and renal cell carcinoma cell line[1].
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MP-1 | MP-1 is a potent Fumarate hydratase-dependent hit. MP-1 engages an array of functional cysteines, including one lying in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. MP-1 causes fumarate hydratase-dependent synthetic lethality in a metastatic hereditary leiomyomatosis and renal cell carcinoma cell line. | |||||||||||||||||||||
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Keywords
