2054938-28-0
2054938-28-0
Chemical Structure
Plinabulin-d1
Synonym(s): NPI-2358-d1
- CAS No.: 2054938-28-0
- Formula:C19H19DN4O2
- Molecular Weight:337.39
IUPAC Name: (Z)-3-((Z)-benzylidene)-6-((4-(tert-butyl)-1H-imidazol-5-yl)methylene-d)piperazine-2,5-dione
InChIKey: UNRCMCRRFYFGFX-JTSGUJNOSA-N
SMILES: CC(C)(C)C(N=CN1)=C1/C([2H])=C2C(N/C(C(N/2)=O)=C\C3=CC=CC=C3)=O
Biological Activity: Plinabulin-d1 is an active compound.
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Plinabulin-d1 | Plinabulin-d1 is an active compound. | |||||||||||||||||||||
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Plinabulin | 98.0% | Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. | ||||||||||||||||||||
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Keywords
