216158-34-8
216158-34-8
Chemical Structure
ONO-8711
- CAS No.: 216158-34-8
- Formula:C22H30ClNO4S
- Molecular Weight:440.00
IUPAC Name: (Z)-6-((2R,3S)-3-(((4-chloro-2-methylphenyl)sulfonamido)methyl)bicyclo[2.2.2]octan-2-yl)hex-5-enoic acid
InChIKey: VVEXPDRCGCQELD-CFDZEDGGSA-N
SMILES: O=C(O)CCC/C=C\[C@H]1C(CC2)CCC2[C@@H]1CNS(=O)(C3=CC=C(Cl)C=C3C)=O
Biological Activity: ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer[1].
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ONO-8711 | ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer. | |||||||||||||||||||||
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References
Keywords
