2196245-98-2
Chemical Structure
DNS-pE
- CAS No.: 2196245-98-2
- Formula:C14H15NO2S
- Molecular Weight:261.34
IUPAC Name: N,N-dimethyl-6-(vinylsulfonyl)naphthalen-2-amine
InChIKey: LFACUIVWKWTUSE-UHFFFAOYSA-N
SMILES: CN(C)C1=CC=C2C=C(S(=O)(C=C)=O)C=CC2=C1
Biological Activity: DNS-pE is a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor with a Ki of 7.4 μM. DNS-pE selectively and irreversibly covalently modifies endogenous PHGDH in live mammalian cells, its vinyl sulfone moiety acts as a fluorescence quencher that becomes highly fluorescent upon covalent modification of PHGDH. DNS-pE can be used as a fluorescent dye for live-cell imaging[1].
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DNS-pE | DNS-pE is a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor with a Ki of 7.4 μM. DNS-pE selectively and irreversibly covalently modifies endogenous PHGDH in live mammalian cells, its vinyl sulfone moiety acts as a fluorescence quencher that becomes highly fluorescent upon covalent modification of PHGDH. DNS-pE can be used as a fluorescent dye for live-cell imaging. | |||||||||||||||||||||
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Keywords
