2222728-15-4
2222728-15-4
Chemical Structure
ANTXR1-IN-1
- CAS No.: 2222728-15-4
- Formula:C33H32ClNO5
- Molecular Weight:558.06
InChIKey: UVUKBDKAXPWBJV-QPGIRRASSA-M
SMILES: O=C(CC1(C[C@H]2C3)C[C@H]3C[C@H](C2)C1)OC4=C(OC)C=CC5=C4C=[N+](CC6)C7=C5C=CC8=C7C6=CC9=C8OCO9.[Cl-]
Biological Activity: ANTXR1-IN-1 is a ANTXR1 inhibitor with a Ka of 2.88 μM for hANTXR1, and exhibits anti-tumor cell activity. ANTXR1-IN-1 undergoes acylation with Ser229 of ANTXR1, thereby inhibiting tumor cell proliferation. ANTXR1-IN-1 induces G2/M phase arrest and apoptosis in tumor cells. ANTXR1-IN-1 can be used for research on melanoma, non-small cell lung cancer, hepatocellular carcinoma, and colorectal cancer[1].
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ANTXR1-IN-1 | ANTXR1-IN-1 is a ANTXR1 inhibitor with a Ka of 2.88 μM for hANTXR1, and exhibits anti-tumor cell activity. ANTXR1-IN-1 undergoes acylation with Ser229 of ANTXR1, thereby inhibiting tumor cell proliferation. ANTXR1-IN-1 induces G2/M phase arrest and apoptosis in tumor cells. ANTXR1-IN-1 can be used for research on melanoma, non-small cell lung cancer, hepatocellular carcinoma, and colorectal cancer. | |||||||||||||||||||||
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