2304344-56-5
Chemical Structure
CHMFL-ABL-039
- CAS No.: 2304344-56-5
- Formula:C31H33F3N6O3
- Molecular Weight:594.63
IUPAC Name: N-(4-(2-((6-(cyclopropanecarboxamido)pyridin-3-yl)amino)-2-oxoethyl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
InChIKey: RBWVZGKOJYNSAN-UHFFFAOYSA-N
SMILES: O=C(NC1=CN=C(NC(C2CC2)=O)C=C1)CC3=CC=C(NC(C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C3
Biological Activity: CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor with the IC50s of 7.9 nM and 27.9 nM, respectively. CHMFL-ABL-039 is used in the research of chronic myeloid leukemia[1].
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CHMFL-ABL-039 | CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor with the IC50s of 7.9 nM and 27.9 nM, respectively. CHMFL-ABL-039 is used in the research of chronic myeloid leukemia. | |||||||||||||||||||||
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Keywords
