2376726-26-8
Chemical Structure
BTK inhibitor 13
- CAS No.: 2376726-26-8
- Formula:C29H26FN5O3
- Molecular Weight:511.55
IUPAC Name: N-(3-(5-(N-acryloyl-N-methylglycyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropylbenzamide
InChIKey: QLIKETBAAZMMKI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(F)=CC(C2=C3C(NC=C3C(CN(C)C(C=C)=O)=O)=NC=N2)=C1C)C4=CC=C(C5CC5)C=C4
Biological Activity: BTK inhibitor 13 is an orally active Bruton's tyrosine kinase (BTK) inhibitor, with an IC50 value of 1.2 nM against human BTK. BTK inhibitor 13 covalently modifies the Cys481 residue of BTK when binding to the inactive conformation of BTK. BTK inhibitor 13 is used for the research of autoimmune diseases[1].
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BTK inhibitor 13 | BTK inhibitor 13 is an orally active Bruton's tyrosine kinase (BTK) inhibitor, with an IC50 value of 1.2 nM against human BTK. BTK inhibitor 13 covalently modifies the Cys481 residue of BTK when binding to the inactive conformation of BTK. BTK inhibitor 13 is used for the research of autoimmune diseases. | |||||||||||||||||||||
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