2411865-57-9
Chemical Structure
VKT-17-P4-23
- CAS No.: 2411865-57-9
- Formula:C13H16N4O
- Molecular Weight:244.29
InChIKey: MKGKSNNEJIAGIN-UHFFFAOYSA-N
SMILES: O=C(C1=NNC=N1)NCCCCC2=CC=CC=C2
Biological Activity: VKT-17-P4-23 is a blood-brain barrier-permeable DksA inhibitor. DksA is a highly conserved transcriptional regulator in Gram-negative bacteria, with a Kd of 124 μM. Through the DksA-regulated, SPI-2-dependent survival pathway, VKT-17-P4-23 exhibits antibacterial activity against both planktonic and intracellular pathogens such as Salmonella, and also effectively combats persistent bacteria that are difficult to eliminate. VKT-17-P4-23 can be used in studies of Salmonella infection[1].
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VKT-17-P4-23 | VKT-17-P4-23 is a blood-brain barrier-permeable DksA inhibitor. DksA is a highly conserved transcriptional regulator in Gram-negative bacteria, with a Kd of 124 μM. Through the DksA-regulated, SPI-2-dependent survival pathway, VKT-17-P4-23 exhibits antibacterial activity against both planktonic and intracellular pathogens such as Salmonella, and also effectively combats persistent bacteria that are difficult to eliminate. VKT-17-P4-23 can be used in studies of Salmonella infection. | |||||||||||||||||||||
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Keywords
