2416165-76-7
Chemical Structure
AB-3PRGD2
- CAS No.: 2416165-76-7
- Formula:C137H215IN30O45S
- Molecular Weight:3161.32
InChIKey: XWTZSZBTLBDMLZ-BZMBUDQKSA-N
SMILES: OC(CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(N[C@@H](CSC2C(N(CCCCCC(NCCOCCOCCOCCOCCC(N[C@@H](CCC(NCCOCCOCCOCCOCCC(NCCCC[C@@H]3NC([C@@H](CC4=CC=CC=C4)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)=O)=O)=O)C(NCCOCCOCCOCCOCCC(NCCCC[C@@H]5NC([C@@H](CC6=CC=CC=C6)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC5=O)=O)=O)=O)=O)=O)=O)=O)=O)C(C2)=O)=O)C(N[C@H](CCCCNC(CCCC7=CC=C(I)C=C7)=O)C(O)=O)=O)=O)CC1)=O
Biological Activity: AB-3PRGD2 is a radiotherapeutic agent targeting integrin αvβ3. AB-3PRGD2 shows improved tumor uptake and prolonged tumor retention, leading to significantly enhanced tumor growth suppression. AB-3PRGD2 can remodel the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells[1].
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AB-3PRGD2 | AB-3PRGD2 is a radiotherapeutic agent targeting integrin αvβ3. AB-3PRGD2 shows improved tumor uptake and prolonged tumor retention, leading to significantly enhanced tumor growth suppression. AB-3PRGD2 can remodel the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells. | |||||||||||||||||||||
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Keywords
