2484876-94-8
Chemical Structure
Antitumor agent-136
- CAS No.: 2484876-94-8
- Formula:C58H76N10O11S3
- Molecular Weight:1185.48
InChIKey: WJRWRYBOCSUYIN-IWIXZVHYSA-N
SMILES: O=C(C1=CC=C(C=C1)CN2CCN(CC2)S(=O)(C3=CC=C(C=C3)NC(NCC4=CN=CC=C4)=S)=O)NCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O
Biological Activity: Antitumor Agent-136 (Compound 17) is a potent broad-spectrum antitumor agent and a NAMPT inhibitor with an IC50 of 9.5 nM. Antitumor Agent-136 can reduce the levels of intracellular and extracellular NAMPT protein through the ubiquitin proteasome pathway, thus achieving tumor inhibition[1].
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Antitumor agent-136 | Antitumor Agent-136 (Compound 17) is a potent broad-spectrum antitumor agent and a NAMPT inhibitor with an IC50 of 9.5 nM. Antitumor Agent-136 can reduce the levels of intracellular and extracellular NAMPT protein through the ubiquitin proteasome pathway, thus achieving tumor inhibition. | |||||||||||||||||||||
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Keywords
