2488296-74-6
Chemical Structure
MTX-23
Synonym(s): PROTAC AR-V7 degrader-2
- CAS No.: 2488296-74-6
- Formula:C43H53F2N7O7S2
- Molecular Weight:882.05
IUPAC Name: 1-(2,4-dichloropyrimidin-5-yl)ethan-1-ol
InChIKey: JOZGICGAZBMCJF-JMSDHYLISA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
Biological Activity: MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC50 values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MTX-23 | 99.79% | MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC50 values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer. | ||||||||||||||||||||
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Keywords
