254737-29-6
254737-29-6
Chemical Structure
2-MPPA
Synonym(s): GPI-5693
- CAS No.: 254737-29-6
- Formula:C8H14O4S
- Molecular Weight:206.26
IUPAC Name: 2-(3-mercaptopropyl)pentanedioic acid
InChIKey: FNLNSQHJKVQCBP-UHFFFAOYSA-N
SMILES: O=C(O)C(CCCS)CCC(O)=O
Biological Activity: 2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM[1][2].
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2-MPPA | 98.0% | 2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM. | ||||||||||||||||||||
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2-MPPA (Standard) | ≥98% | 2-MPPA (Standard) is the analytical standard of 2-MPPA. This product is intended for research and analytical applications. 2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM. | ||||||||||||||||||||
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References
- [1]. Takatsu Y, et al. Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice. Brain Res. 2011 Jan 31;1371:82-6. [Content Brief]
- [2]. She Y, et al. 2-MPPA, a selective inhibitor of PSMA, delays prostate cancer growth and attenuates taxol-induced neuropathy in mice. Journal of Clinical Oncology, 2005, 23(16_suppl): 8054-8054.
Keywords
