2566525-18-4
2566525-18-4
Chemical Structure
AKE-72
- CAS No.: 2566525-18-4
- Formula:C30H29F3N6O
- Molecular Weight:546.59
InChIKey: XAXJKDYUXBSJJT-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=CC(C#CC4=CC=CC5=C4C(N)=NN5)=C3
Biological Activity: AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABLWT, BCR-ABLT315, BCR-ABLE255K, BCR-ABLF3171, BCR-ABLH396P and BCR-ABLQ252H with IC50s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AKE-72 | 98.29% | AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABLWT, BCR-ABLT315, BCR-ABLE255K, BCR-ABLF3171, BCR-ABLH396P and BCR-ABLQ252H with IC50s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line. | ||||||||||||||||||||
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References
Keywords
