2648799-49-7
2648799-49-7
Chemical Structure
FLT3/D835Y-IN-1
- CAS No.: 2648799-49-7
- Formula:C22H21N5O3
- Molecular Weight:403.43
IUPAC Name: (2Z,3E)-3-((2-oxo-2-(piperazin-1-yl)ethoxy)imino)-[2,3'-biindolinylidene]-2'-one
InChIKey: ROMHIQSFQAUVMM-OQBIKMBDSA-N
SMILES: O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCC(N5CCNCC5)=O
Biological Activity: FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC50 values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia)[1].
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FLT3/D835Y-IN-1 | FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC50 values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia). | |||||||||||||||||||||
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References
Keywords
