272445-72-4
Chemical Structure
8-pCPT-cGMP-AM
Synonym(s): 8-(4-Chlorophenylthio)-cGMP-AM
- CAS. Nr.: 272445-72-4
- Formula:C19H19ClN5O9PS
- Molecular Weight:559.87
IUPAC Name: (((4aR,6R,7R,7aS)-6-(2-amino-8-((4-chlorophenyl)thio)-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl acetate
InChIKey: LCCKFSJPABZYBA-OBOZOENMSA-N
SMILES: O[C@@H]1[C@H](OP2(OCOC(C)=O)=O)[C@@H](CO2)O[C@H]1N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=C(N)NC5=O
Biological Activity: 8-pCPT-cGMP-AM (8-(4-Chlorophenylthio)-cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation[1].
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8-pCPT-cGMP-AM | 8-pCPT-cGMP-AM (8-(4-Chlorophenylthio)-cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation. | |||||||||||||||||||||
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Keywords
