2752669-00-2
Chemical Structure
N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol
- CAS No.: 2752669-00-2
- Formula:C19H37N7O7S
- Molecular Weight:507.60
IUPAC Name: N,N-bis(2-(2-(2-azidoethoxy)ethoxy)ethyl)-3-(2-(2-mercaptoethoxy)ethoxy)propanamide
InChIKey: WBTPNNNIFUAJFO-UHFFFAOYSA-N
SMILES: O=C(CCOCCOCCS)N(CCOCCOCCN=[N+]=[N-])CCOCCOCCN=[N+]=[N-]
Biological Activity: N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol | N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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Keywords
