2757728-47-3
2757728-47-3
Chemical Structure
KDX1381
- CAS No.: 2757728-47-3
- Formula:C32H32F2N6O4S
- Molecular Weight:634.70
InChIKey: PDUWTNSNRYDIMZ-UHFFFAOYSA-N
SMILES: FC1=CC=CC(O)=C1C2=CC=C(S(NCCN3CCC(CN4C=C(C5=C(C(C)=O)NC6=C5C=C(F)C=C6)N=N4)CC3)(=O)=O)C=C2
Biological Activity: KDX1381 is a bivalent CK2α inhibitor (IC50: 17 nM, KD: 54 nM). KDX1381 has antitumor activity in mouse 786-O and A375 tumor xenograft models. KDX1381 combined with VEGFR inhibitors or DNA damaging agents enhances antitumor efficacy in mouse hepatocellular carcinoma and glioma models[1].
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KDX1381 | KDX1381 is a bivalent CK2α inhibitor (IC50: 17 nM, KD: 54 nM). KDX1381 has antitumor activity in mouse 786-O and A375 tumor xenograft models. KDX1381 combined with VEGFR inhibitors or DNA damaging agents enhances antitumor efficacy in mouse hepatocellular carcinoma and glioma models. | |||||||||||||||||||||
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References
Keywords
