2764786-56-1
Chemical Structure
NS5A-IN-3
- CAS No.: 2764786-56-1
- Formula:C44H44N6O8
- Molecular Weight:784.86
IUPAC Name: dimethyl ((1R,1'R)-((2S,2'S)-(((ethyne-1,2-diylbis(3,1-phenylene))bis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate
InChIKey: DLGIPJILEDVCCU-CDBYGCFJSA-N
SMILES: COC(N[C@H](C1=CC=CC=C1)C(N2CCC[C@H]2C(NC3=CC(C#CC4=CC(NC([C@@H]5CCCN5C([C@@H](C6=CC=CC=C6)NC(OC)=O)=O)=O)=CC=C4)=CC=C3)=O)=O)=O
Biological Activity: NS5A-IN-3 (Compound 15) is a potent inhibitor of NS5A. NS5A-IN-3 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability. NS5A-IN-3 exhibits a higher resistance barrier than daclatasvir against genotype 1b[1]. NS5A-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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NS5A-IN-3 | NS5A-IN-3 (Compound 15) is a potent inhibitor of NS5A. NS5A-IN-3 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability. NS5A-IN-3 exhibits a higher resistance barrier than daclatasvir against genotype 1b. NS5A-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Keywords
