2770246-69-8
2770246-69-8
Chemical Structure
HSD17B13-IN-35
- CAS 番号: 2770246-69-8
- Formula:C25H16Cl2FN5O3
- Molecular Weight:524.33
InChIKey: HFMBTNIIAHHRKR-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=C(C(Cl)=C1)O)NC2=CC=CC(N=CN3CC4=NN(C5=C(F)C=CC=C5)C=C4)=C2C3=O
Biological Activity: HSD17B13-IN-35 (compound 76) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM? estradiol? as substrates. HSD17B13-IN-35? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-35 | HSD17B13-IN-35 (compound 76) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM? estradiol? as substrates. HSD17B13-IN-35? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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References
Keywords
