292065-64-6
Chemical Structure
TDRL-X80
- CAS No.: 292065-64-6
- Formula:C23H15ClN2O6
- Molecular Weight:450.83
IUPAC Name: (E)-5-(5-((1-(3-carboxyphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid
InChIKey: XZRBYOCWWJMJRZ-GZTJUZNOSA-N
SMILES: O=C(O)C1=CC(C2=CC=C(/C=C3C(C)=NN(C4=CC=CC(C(O)=O)=C4)C\3=O)O2)=CC=C1Cl
Biological Activity: TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis[1].
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TDRL-X80 | 99.6% | TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis. | ||||||||||||||||||||
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Keywords
