2922732-38-3
Chemical Structure
RMC-9945
Synonym(s): RM-044
- CAS No.: 2922732-38-3
- Formula:C60H80F3N11O6S
- Molecular Weight:1140.41
InChIKey: ILULIGPRCUMTCR-VZYWVMDKSA-N
SMILES: FC(F)(F)CN1[C@]([C@]2=C(N=CC(N3CCN(C4CC4)CC3)=C2)[C@H](C)OC)=C5C6=CC(C7=CSC(C[C@@H](C(N8N[C@](CCC8)([H])C(OCC(C)(C5)C)=O)=O)NC([C@@H](N9C[C@]%10(CN(CC%10)C([C@H]%11[C@@H](C%12CC%12)N%11C)=O)CC9)C(C)C)=O)=N7)=CC=C61
Biological Activity: RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1+ state to the Lgr5+ stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma[1][2][3].
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RMC-9945 | RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1+ state to the Lgr5+ stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma. | |||||||||||||||||||||
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- [1]. Centonze A, et al. A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer. Cancer discovery. 2026 Feb 06;16(2):320-344. [Content Brief]
- [2]. Bu J, et al. Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers. MedComm (2020). 2025 Dec 3;6(12):e70513. doi: 10.1002/mco2.70513. [Content Brief]
- [3]. Vincent A, et al. Pancreatic cancer. Lancet (London, England). 2011 Aug 13;378(9791):607-20. [Content Brief]
Keywords
