3024060-23-6
3024060-23-6
Chemical Structure
KRAS G12D-IN-31
- CAS. Nr.: 3024060-23-6
- Formula:C38H44F2N8O3
- Molecular Weight:698.80
InChIKey: RBXYRZINWSBDRK-RJNCKGSUSA-N
SMILES: OC1=CC(C=CC(F)=C2CC)=C2C(N3CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7CC8=C9C(C(N(CC9)C)=O)=NN8CCC7)=C4CC3)=C1
Biological Activity: KRAS G12D-IN-31 is a potent KRAS G12D inhibitor with an IC50 of < 100 nM. KRAS G12D-IN-31 inhibits the proliferation of RAS-dependent cells (KRASG12C, KRAS G12D, KRASG12V and KRASWT). KRAS G12D-IN-31 can be used to study non-small cell lung cancer, gastric cancer, colon cancer, and malignant melanoma[1].
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KRAS G12D-IN-31 | 98.53% | KRAS G12D-IN-31 is a potent KRAS G12D inhibitor with an IC50 of < 100 nM. KRAS G12D-IN-31 inhibits the proliferation of RAS-dependent cells (KRASG12C, KRAS G12D, KRASG12V and KRASWT). KRAS G12D-IN-31 can be used to study non-small cell lung cancer, gastric cancer, colon cancer, and malignant melanoma. | ||||||||||||||||||||
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References
Keywords
