3036530-43-2
3036530-43-2
Chemical Structure
BRD4 degrader-2
- CAS No.: 3036530-43-2
- Formula:C34H33ClN6O4S
- Molecular Weight:657.18
InChIKey: WJQUXZKGMGEUTI-DEIPZHPTSA-N
SMILES: ClC1=CC=C(C2=N[C@@H](CC(N3CCN(C(/C=C/C(C4=CC=C(OC)C=C4)=O)=O)CC3)=O)C5=NN=C(C)N5C6=C2C(C)=C(C)S6)C=C1
Biological Activity: BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1][2].
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BRD4 degrader-2 | BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells. | |||||||||||||||||||||
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References
Keywords
