3040919-39-6
Chemical Structure
PDIC-NN dimethanesulfonate
Synonym(s): PDIC-NS
- CAS No.: 3040919-39-6
- Formula:C34H32Cl4N4O10S2
- Molecular Weight:862.58
InChIKey: SFBAOLKOPZKFLZ-UHFFFAOYSA-N
SMILES: O=C1N(C(C2=C(C3=C4C(Cl)=C2)C1=CC(Cl)=C3C5=C(C=C(C6=C7C=C(C4=C56)Cl)C(N(C7=O)CC[NH+](C)C)=O)Cl)=O)CC[NH+](C)C.CS(=O)([O-])=O.CS(=O)([O-])=O
Biological Activity: PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response[1][2].
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PDIC-NN dimethanesulfonate | PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response. | |||||||||||||||||||||
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References
- [1]. Wang S, et al. Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenases by bisphenol A analogues depends on their hydrophobicity: in silico docking analysis[J]. Chemico-Biological Interactions, 2024: 111251. [Content Brief]
- [2]. Zhao X, et al. Sulfonated Perylene as Three-in-One STING Agonist for Cancer Chemo-Immunotherapy. Angew Chem Int Ed Engl. 2024 Mar 11;63(11):e202318799. [Content Brief]
