3052618-54-6
Chemical Structure
WCY-8-67
- CAS No.: 3052618-54-6
- Formula:C25H32FN7
- Molecular Weight:449.57
IUPAC Name: N1-(6-(4-fluoronaphthalen-1-yl)-2-(piperazin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-N1,N2,N2-trimethylethane-1,2-diamine
InChIKey: VRNBGGWMPJZSGQ-UHFFFAOYSA-N
SMILES: CN(C)CCN(C1=C2C(CN(C3=C4C=CC=CC4=C(F)C=C3)C2)=NC(N5CCNCC5)=N1)C
Biological Activity: WCY-8-67 is an orally active and selective USP5 inhibitor, with an IC50 value of 1.33 μM. WCY-8-67 induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways in vitro. WCY-8-67 inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 can be used for the study of acute myeloid leukemia[1].
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WCY-8-67 | WCY-8-67 is an orally active and selective USP5 inhibitor, with an IC50 value of 1.33 μM. WCY-8-67 induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways in vitro. WCY-8-67 inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 can be used for the study of acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
