3059058-07-7
Chemical Structure
MOZ-IN-3
- CAS No.: 3059058-07-7
- Formula:C17H13FN2O3S
- Molecular Weight:344.36
InChIKey: RMNWCAVVOGDRGR-UHFFFAOYSA-N
SMILES: FC1=C(C(CNS(=O)(C2=CC=CC3=C2N=CC=C3)=O)=O)C=CC=C1
Biological Activity: MOZ-IN-3 is an orally active KAT6A (MOZ) inhibitor with an IC50 of 0.03 μM against human targets, and it exhibits high selectivity over other MYST family histone acetyltransferases. MOZ-IN-3 modulates monocyte function, exerts anti-tumor effects, increases the nucleocytoplasmic ratio, and enhances cellular resistance to chemotherapeutic drug-induced cell death. MOZ-IN-3 is applicable to leukemia-related research[1][2][3].
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MOZ-IN-3 | 98.75% | MOZ-IN-3 is an orally active KAT6A (MOZ) inhibitor with an IC50 of 0.03 μM against human targets, and it exhibits high selectivity over other MYST family histone acetyltransferases. MOZ-IN-3 modulates monocyte function, exerts anti-tumor effects, increases the nucleocytoplasmic ratio, and enhances cellular resistance to chemotherapeutic drug-induced cell death. MOZ-IN-3 is applicable to leukemia-related research. | ||||||||||||||||||||
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- [1]. Duan Y, et al. Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy. European journal of medicinal chemistry. 2023 Nov 15;260:115770. [Content Brief]
- [2]. Jiang M, et al. MOZ Forms an Autoregulatory Feedback Loop with miR-223 in AML and Monocyte/Macrophage Development. iScience. 2019 Jan 25;11:189-204. [Content Brief]
- [3]. Chen X, et al. Hierarchical small molecule inhibition of MYST acetyltransferases. Nature Communications, 2026, 17: 4329.
Keywords
