3077081-47-8
Chemical Structure
RBM1-151
- CAS No.: 3077081-47-8
- Formula:C28H41NO5
- Molecular Weight:471.63
IUPAC Name: N-((2S,3R,E)-3-hydroxy-7-((2-oxo-2H-chromen-7-yl)oxy)hept-5-en-2-yl)dodecanamide
InChIKey: BQAOJEDORNZRBA-LLYJWUDESA-N
SMILES: CCCCCCCCCCCC(N[C@@H](C)[C@H](O)C/C=C/COC1=CC=C(C=CC(O2)=O)C2=C1)=O
Biological Activity: RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 (HY-150163), as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em). RBM1-151 is hydrolyzed by acid ceramidase (AC) ((appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase (appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) (appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer)[1][2].
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RBM1-151 | RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 (HY-150163), as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em). RBM1-151 is hydrolyzed by acid ceramidase (AC) ((appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase (appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) (appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer). | |||||||||||||||||||||
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- [1]. Casasampere M, et al. A fluorogenic substrate for the detection of lipid amidases in intact cells. J Lipid Res. 2024 Mar;65(3):100520. [Content Brief]
- [2]. Ciuffreda P, et al. Fluorescence-Based Enzyme Activity Assay: Ascertaining the Activity and Inhibition of Endocannabinoid Hydrolytic Enzymes. Int J Mol Sci. 2024 Jul 13;25(14):7693. [Content Brief]
Keywords
