3087298-90-3
Chemical Structure
EGFR-IN-208
- CAS No.: 3087298-90-3
- Formula:C32H30FN5O
- Molecular Weight:519.61
InChIKey: AEZAGTCANQTLQJ-UHFFFAOYSA-N
SMILES: CC1=CC(NC(C2=CC=C3C=CC(C4=CC=C(C=C4)N5CCNCC5)=NC3=C2O)C6=CC(F)=CC=C6)=NC=C1
Biological Activity: EGFR-IN-208 is an allosteric mutant EGFRL858R/T790M and EGFRL858R/T790M/C797S inhibitor, with IC50 values of 3.06 μM and 1.08 μM, respectively. EGFR-IN-208 binds to the allosteric site of EGFR and inhibits EGFR phosphorylation. EGFR-IN-208 induces apoptosis and exhibits antiproliferative effects in cancer cells. EGFR-IN-208 can be used in research related to non-small cell lung cancer[1].
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EGFR-IN-208 | EGFR-IN-208 is an allosteric mutant EGFRL858R/T790M and EGFRL858R/T790M/C797S inhibitor, with IC50 values of 3.06 μM and 1.08 μM, respectively. EGFR-IN-208 binds to the allosteric site of EGFR and inhibits EGFR phosphorylation. EGFR-IN-208 induces apoptosis and exhibits antiproliferative effects in cancer cells. EGFR-IN-208 can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
