3115765-38-0
Chemical Structure
dAurAB2
- CAS No.: 3115765-38-0
- Formula:C52H62BrN11O8
- Molecular Weight:1049.02
InChIKey: MLNBHVAPALPWDP-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCCCCCCC(N1CCN(C2=CC=C(C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3)C=C2)CC1)=O)COC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O
Biological Activity: dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC50s of 59 nM and 39 nM, respectively. dAurAB2 reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. dAurAB2 can be used for the study of neuroblastoma. (Pink, Aurora ligand (HY-10804); Blue, E3 ligand: (HY-103597); Black, linker (HY-W105740))[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dAurAB2 | 98.61% | dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC50s of 59 nM and 39 nM, respectively. dAurAB2 reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. dAurAB2 can be used for the study of neuroblastoma. (Pink, Aurora ligand (HY-10804); Blue, E3 ligand: (HY-103597); Black, linker (HY-W105740)). | ||||||||||||||||||||
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Keywords
