345915-10-8
Chemical Structure
AZD3409
Synonym(s): EBP-921
- CAS No.: 345915-10-8
- Formula:C34H41FN4O4S2
- Molecular Weight:652.84
IUPAC Name: isopropyl (2-(4-fluorophenethyl)-5-((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzoyl)-L-methioninate
InChIKey: HKGUHEGKBLYKHY-QMOZSOIISA-N
SMILES: O=C(N[C@@H](CCSC)C(OC(C)C)=O)C1=CC(NC[C@H]2NC[C@H](C2)SC(C3=CN=CC=C3)=O)=CC=C1CCC4=CC=C(F)C=C4
Biological Activity: AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC50s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer[1].
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AZD3409 | AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC50s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer. | |||||||||||||||||||||
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Keywords
