357425-02-6
357425-02-6
Chemical Structure
CP-601927
- CAS. Nr.: 357425-02-6
- Formula:C12H12F3N
- Molecular Weight:227.23
IUPAC Name: (1R,5S)-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine
InChIKey: RNOBTWYQAWEZHH-JGVFFNPUSA-N
SMILES: FC(C1=CC=C2[C@@H](C3)CNC[C@@H]3C2=C1)(F)F
Biological Activity: CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties[1][2].
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CP-601927 | 98.24% | CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties. | ||||||||||||||||||||
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References
- [1]. Campion SN, et al. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011;92(4):323-332. [Content Brief]
- [2]. Mineur YS, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011;22(4):291-299. [Content Brief]
Keywords
