461450-30-6
Chemical Structure
MRK-898
- CAS No.: 461450-30-6
- Formula:C20H9F5N4
- Molecular Weight:400.30
IUPAC Name: 2',4-difluoro-5'-(7-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-yl)-[1,1'-biphenyl]-2-carbonitrile
InChIKey: XXRKXVKJMSIZSM-UHFFFAOYSA-N
SMILES: N#CC1=CC(F)=CC=C1C2=C(F)C=CC(C3=CN=C4N=C(C(F)(F)F)C=CN43)=C2
Biological Activity: MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s)[1].
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MRK-898 | 99.48% | MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s). | ||||||||||||||||||||
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Keywords
