542-40-5
Chemical Structure
Norbixin
- CAS No.: 542-40-5
- Formula:C24H28O4
- Molecular Weight:380.48
InChIKey: ZVKOASAVGLETCT-UOGKPENDSA-N
SMILES: O=C(O)/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O
Biological Activity: Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS, chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H2O2-induced mutagenesis, activates PPAR-α, modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin (HY-N6884). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye[1][2][3][4].
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Norbixin | Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS, chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H2O2-induced mutagenesis, activates PPAR-α, modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin (HY-N6884). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye. | |||||||||||||||||||||
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- [1]. Fontaine V, et al. Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo. PloS one. 2016;11(12):e0167793. [Content Brief]
- [2]. Witono JR, et al. The potency of norbixin as an active compound of natural dye in textile industry. Materials Today: Proceedings, 2022, 63(Supplement 1):S248-S254.
- [3]. Kovary K, et al. Biochemical behaviour of norbixin during in vitro DNA damage induced by reactive oxygen species. The British journal of nutrition. 2001 Apr;85(4):431-40. [Content Brief]
- [4]. Roehrs M, et al. Bixin and norbixin have opposite effects on glycemia, lipidemia, and oxidative stress in streptozotocin-induced diabetic rats. International journal of endocrinology. 2014;2014:839095. [Content Brief]
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