542-40-5
Chemical Structure
Norbixin
- CAS No.: 542-40-5
- Formula:C24H28O4
- Molecular Weight:380.48
IUPAC Name: (2E,4E,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid
InChIKey: ZVKOASAVGLETCT-UOGKPENDSA-N
SMILES: O=C(O)/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O
Biological Activity: Norbixin is a carotenoid that has been found in B. orellana.It binds to PPARγ in a cell-free assay (Ki = 1.15 μM)[1]. Norbixin attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome[2][3].
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Norbixin | Norbixin is a carotenoid that has been found in B. orellana.It binds to PPARγ in a cell-free assay (Ki = 1.15 μM). Norbixin attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome. | |||||||||||||||||||||
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- [1]. A, R., Agrawal, N., Kumar, H., et al. Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic syndrome: Validation by in silico and in vivo experimental assessment. Life Sci. 209, 69-77 (2018). [Content Brief]
- [2]. Somacal, S., Quatrin, A., Ruviaro, A.R., et al. Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation. Food Res. Int. 159, 111522 (2022). [Content Brief]
- [3]. Barcelos, G.R.M., Grotto, D., Serpeloni, J.M., et al. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ. Mol. Mutagen. 53(7), 535-541 (2012). [Content Brief]
Keywords
