74842-47-0
Chemical Structure
3-O-Demethylfortimicin A
Synonym(s): A-49759
- CAS No.: 74842-47-0
- Formula:C16H33N5O6
- Molecular Weight:391.46
IUPAC Name: 2-amino-N-(4-amino-3-((3-amino-6-(1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5,6-trihydroxycyclohexyl)-N-methylacetamide
InChIKey: OWTJVZIKRRJXGS-UHFFFAOYSA-N
SMILES: NCC(N(C)[C@@H]1[C@H]([C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2O[C@@H](CC[C@H]2N)[C@H](C)N)N)O)O)=O
Biological Activity: 3-O-Demethylfortimicin A (A-49759) is an aminocyclitol antibiotic with antibacterial activity. 3-O-Demethylfortimicin A is particularly effective against Gram-negative pathogens and staphylococcus[1][2][3].
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3-O-Demethylfortimicin A | 3-O-Demethylfortimicin A (A-49759) is an aminocyclitol antibiotic with antibacterial activity. 3-O-Demethylfortimicin A is particularly effective against Gram-negative pathogens and staphylococcus. | |||||||||||||||||||||
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- [1]. Sennello LT, et al. Single-dose pharmacokinetics of 3-O-demethylfortimicin A in humans after intravenous and intramuscular administration. Antimicrob Agents Chemother. 1986 Mar;29(3):400-4. [Content Brief]
- [2]. Girolami RL, et al. Comparative antimicrobial activity of O-demethylfortimicin A, a derivative of fortimicin A. Antimicrob Agents Chemother. 1980 Nov;18(5):766-72. [Content Brief]
- [3]. Yang CL, et al. Comparative vestibular toxicity study with 3-O-demethylfortimicin A disulfate and gentamicin sulfate in cats. Drug Chem Toxicol. 1987;10(3-4):237-56. [Content Brief]
Keywords
