748777-47-1
748777-47-1
Chemical Structure
CCT077791
- CAS No.: 748777-47-1
- Formula:C9H5ClN2O3S
- Molecular Weight:256.67
IUPAC Name: 5-chloro-2-(4-nitrophenyl)isothiazol-3(2H)-one
InChIKey: RBOAUBASDMUWJM-UHFFFAOYSA-N
SMILES: O=C1C=C(SN1C2=CC=C([N+]([O-])=O)C=C2)Cl
Biological Activity: CCT077791 is a PCAF (IC50: 7.3 μM (FlashPlate); 2.2 μM (Filter assay)) and p300 histone acetyltransferase inhibitor. CCT077791 reduces total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of α-tubulin. CCT077791 can be used in the research of colorectal cancer[1].
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CCT077791 | CCT077791 is a PCAF (IC50: 7.3 μM (FlashPlate); 2.2 μM (Filter assay)) and p300 histone acetyltransferase inhibitor. CCT077791 reduces total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of α-tubulin. CCT077791 can be used in the research of colorectal cancer. | |||||||||||||||||||||
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References
Keywords
