774546-16-6
Chemical Structure
AN-465
- CAS No.: 774546-16-6
- Formula:C24H39N3O4
- Molecular Weight:433.58
InChIKey: MKYVGUHZQZBZDU-UHFFFAOYSA-N
SMILES: CCOC1=C(OCC(NC2CCCCC2)=O)C=CC(CNCCCN3CCOCC3)=C1
Biological Activity: AN-465 is a METTL3 inhibitor with an IC50 of 1.782 μM and a Kd of 8.75 μM against human METTL3. AN-465 reduces m6A modification of RNA, including EV71 2C region RNA, and disrupts the interaction between METTL3 and EV71 2C RNA. AN-465 decreases EV71-induced proinflammatory cytokine production, modulates immune cell phenotypes, alleviates EV71-induced apoptosis, restores autophagic flux, and reduces viral particle formation. AN-465 is used in the study of hand, foot and mouth disease[1].
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AN-465 | AN-465 is a METTL3 inhibitor with an IC50 of 1.782 μM and a Kd of 8.75 μM against human METTL3. AN-465 reduces m6A modification of RNA, including EV71 2C region RNA, and disrupts the interaction between METTL3 and EV71 2C RNA. AN-465 decreases EV71-induced proinflammatory cytokine production, modulates immune cell phenotypes, alleviates EV71-induced apoptosis, restores autophagic flux, and reduces viral particle formation. AN-465 is used in the study of hand, foot and mouth disease. | |||||||||||||||||||||
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