887647-69-0
Chemical Structure
YM-355179 fumarate
- CAS No.: 887647-69-0
- Formula:C33H35FN4O7
- Molecular Weight:618.65
IUPAC Name: (R)-N-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-2-(1-(3-hydroxy-5-methylpicolinoyl)piperidin-4-ylidene)acetamide fumarate
InChIKey: UVJWZUCQVIYFLT-FMYYAHIMSA-N
SMILES: O=C(N[C@H]1CN(CC2=CC=C3C=C(F)C=CC3=C2)CC1)/C=C4CCN(C(C5=NC=C(C)C=C5O)=O)CC\4.O=C(O)/C=C/C(O)=O
Biological Activity: YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively[1].
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YM-355179 fumarate | YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively. | |||||||||||||||||||||
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Keywords
