919351-41-0
919351-41-0
Chemical Structure
AZD1283
- CAS No.: 919351-41-0
- Formula:C23H26N4O5S
- Molecular Weight:470.54
IUPAC Name: ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate
InChIKey: NEMHKCNXXRQYRF-UHFFFAOYSA-N
SMILES: CC1=C(C(OCC)=O)C=C(C#N)C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)=N1
Biological Activity: AZD1283 is a potent P2Y12 receptor antagonist with a binding IC50 of 11 nM and a GTPγS IC50 of 25 nM. AZD1283 has excellent antiplatelet aggregation potency. AZD1283 can be used to research thromboembolic disorders[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD1283 | 99.33% | AZD1283 is a potent P2Y12 receptor antagonist with a binding IC50 of 11 nM and a GTPγS IC50 of 25 nM. AZD1283 has excellent antiplatelet aggregation potency. AZD1283 can be used to research thromboembolic disorders. | ||||||||||||||||||||
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References
- [1]. Kong D, et al. Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. J Med Chem. 2019 Mar 28;62(6):3088-3106. [Content Brief]
- [2]. Bach P, et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24. [Content Brief]
Keywords
