958457-44-8
Chemical Structure
GSK932121
- CAS No.: 958457-44-8
- Formula:C20H15ClF3NO4
- Molecular Weight:425.79
IUPAC Name: 3-chloro-6-(hydroxymethyl)-2-methyl-5-(4-(4-(trifluoromethoxy)phenoxy)phenyl)pyridin-4(1H)-one
InChIKey: QGQFNQWZHHSZIC-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(C)NC(CO)=C1C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2
Biological Activity: GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies[1].
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GSK932121 | GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies. | |||||||||||||||||||||
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Keywords
