Art. -Nr.: HY-B0914

10-Undecenoic acid,98% (stabilized with TBC)

(Synonyms: Undecylenic acid)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.

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Reinheit: 99.99%
CAS. Nr.: 112-38-9
Formel: C₁₁H₂₀O₂
Molecular Weight:184.28

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

10-Undecenoic acid,98% (stabilized with TBC) Chemical Structure

CAS. Nr.: 112-38-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Preparations (1.6-3.8 mM; 3-6 h) of 10-Undecenoic acid complexed with L-arginine induces apoptosis in tumor cells (A549 and Jurkat)^[2].
10-Undecenoic acid (24 h) shows dose-dependent cytotoxicity to human tumor cell lines HeLa, A549, Jurkat, and U937, with IC₅₀s of 0.9862, 0.3751, 0.5782, 0.2893 mM, respectively^[2].
10-Undecenoic acid (up to 5 μM) significantly increases the expression and activity of alkaline phosphatase and calcium deposition, and induces the expression of the osteocalcin gene in mouse osteoblastic MC3T3-E1 subclone 4 cells and primary mouse calvarial cells^[3].
10-Undecenoic acid reduces the number of viable and active cells and makes the biofilm thinner in C. albicans biofilms, while it increases the cell count, metabolic activity and proteinase activity in C. glabrata biofilms^[4].
10-Undecenoic acid (20 μM) shows neuroprotective effect against glutamate, H₂O₂ and Aβ_1-42 induced cell death in SH-SY5Y cells^[5].
10-Undecenoic acid (1-40 mM; 6-24 h) reduces the cell death induced by H₂O₂, partially attenuates the cell death induced by Staurosporine (HY-15141) and Ddoxorubicin (HY-15142A) in SH-SY5Y cells^[6].
10-Undecenoic acid (12.5-50 μg/mL) causes a reduction of LuxS/AI-2QS system in B. subtilis, and (15.625-250 μg/mL) causes a 10-54% reduction of LasI/LasR QS system in P. aeruginosa^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[3]

Cell Line:

Mouse osteoblastic MC3T3-E1 subclone 4 cells, primary mouse calvarial cells
Concentration:

2.5 μM, 5 μM
Incubation Time:

During osteoblast differentiation (up to 18 days for some assays)
Result:

Significantly increased the expression and activity of alkaline phosphatase at day 9 of differentiation (MC3T3-E1 subclone 4 cells).
Induced mineralization at day 15 and 18 (MC3T3-E1 subclone 4 cells).
Significantly induced calcium deposition at differentiation day 28 (primary mouse calvarial cells).
Regulated the mRNA expression levels of osteocalcin (OCN), Fra-2 and NFATc1 in both cell types.

In Vivo

10-Undecenoic acid (arginine undecylenate (GS-1) form, 157.6 mg/mL; topical administration; twice a day; 6 days) effectively clears MRSA infections in the epidermal and dermal layers in a rat model of MRSA skin infection^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 112-38-9
Appearance <23°C Solid,>25°C Liquid
Molecular Weight 184.28
Formel C₁₁H₂₀O₂
Color Off-white to light yellow
SMILES

C=CCCCCCCCCC(O)=O
Synonyms

Undecylenic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Cancer Res

Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non-Small Cell Lung Cancer. [Abstract]

2025 Feb 1;85(3):585-601. PMID: 39514336
Cell Death Differ

PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy. [Abstract]

2024 Sep;31(9):1140-1156. PMID: 38816578

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 50 mg/mL (271.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.4265 mL

27.1326 mL

54.2653 mL

5 mM

1.0853 mL

5.4265 mL

10.8530 mL

10 mM

0.5427 mL

2.7133 mL

5.4265 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (13.57 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (13.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (13.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Brayden DJ, et al. Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative. AAPS J. 2014 Sep;16(5):1064-76. [Content Brief]

[2]. Day ZI, et al. Novel Formulation of Undecylenic Acid induces Tumor Cell Apoptosis. Int J Mol Sci. 2022 Nov 16;23(22):14170. [Content Brief]

[3]. Kim MH, et al. Stimulatory effect of undecylenic acid on mouse osteoblast differentiation. Phytother Res. 2010 Apr;24(4):559-64. [Content Brief]

[4]. Gonçalves LM, et al. Effects of undecylenic acid released from denture liner on Candida biofilms. J Dent Res. 2012 Oct;91(10):985-9. [Content Brief]

[5]. Lee E, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain. Eur J Pharm Sci. 2012 May 12;46(1-2):17-25. [Content Brief]

[6]. Jantas D, et al. An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. J Cell Biochem. 2015 Dec;116(12):2882-95. [Content Brief]

[7]. Fernandes S, et al. Curcumin and 10-undecenoic acid as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int. 2023 Mar;165:112519. [Content Brief]

[8]. Mayfosh A, et al. A Novel Ammonium Carboxylate Salt of Undecylenic Acid for the Topical Treatment of Gram-Positive and Antibiotic-Resistant Skin Infections. Exp Dermatol. 2025 Mar;34(3):e70075. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.4265 mL	27.1326 mL	54.2652 mL	135.6631 mL
	5 mM	1.0853 mL	5.4265 mL	10.8530 mL	27.1326 mL
	10 mM	0.5427 mL	2.7133 mL	5.4265 mL	13.5663 mL
	15 mM	0.3618 mL	1.8088 mL	3.6177 mL	9.0442 mL
	20 mM	0.2713 mL	1.3566 mL	2.7133 mL	6.7832 mL
	25 mM	0.2171 mL	1.0853 mL	2.1706 mL	5.4265 mL
	30 mM	0.1809 mL	0.9044 mL	1.8088 mL	4.5221 mL
	40 mM	0.1357 mL	0.6783 mL	1.3566 mL	3.3916 mL
	50 mM	0.1085 mL	0.5427 mL	1.0853 mL	2.7133 mL
	60 mM	0.0904 mL	0.4522 mL	0.9044 mL	2.2611 mL
	80 mM	0.0678 mL	0.3392 mL	0.6783 mL	1.6958 mL
	100 mM	0.0543 mL	0.2713 mL	0.5427 mL	1.3566 mL

Keywords

10-Undecenoic acid,98% (stabilized with TBC)

2 Cited Publications

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10-Undecenoic acid,98% (stabilized with TBC)

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Publications Citing Use of MedChemExpress (MCE) 10-Undecenoic acid,98% (stabilized with TBC)

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

10-Undecenoic acid,98% (stabilized with TBC) Related Classifications

HY-B0914 Related Classifications