Art. -Nr.: HY-D0185

2'-Deoxyguanosine monohydrate

Name: 2'-Deoxyguanosine monohydrate
Brand: MedChemExpress
SKU: HY-D0185
Price: 25.00 USD
Availability: InStock
Rating: 5 (6 reviews)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and 2'-deoxyribose, and it is one of the basic structural units of DNA. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which in turn may affect gene expression or induce cancer.

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Reinheit: 99.70%
CAS. Nr.: 312693-72-4
Formel: C₁₀H₁₅N₅O₅
Molecular Weight:285.26

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

2'-Deoxyguanosine monohydrate Chemical Structure

CAS. Nr.: 312693-72-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Oxidation products of 2'-Deoxyguanosine monohydrate may be involved in DNA damage, which in turn may affect gene expression or induce cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 312693-72-4
Appearance Solid
Molecular Weight 285.26
Formel C₁₀H₁₅N₅O₅
Color White to off-white
SMILES

O[C@H]1C[C@H](N2C=NC3=C2N=C(NC3=O)N)O[C@@H]1CO.O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

All Microbiological AssayWBELISA

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Journal Impact Factor

Cell Rep

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP. [Abstract]

2020 May 12;31(6):107640. PMID: 32402273
Cell Rep

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation. [Abstract]

2020 Mar 31;30(13):4370-4385.e7. PMID: 32234474

2'-Deoxyguanosine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Mar 31;30(13):4370-4385.e7. [Abstract]

THP-1PMA 167 cells were infected by SFTSV (MOI = 10) for 24 hours in the presence of 2'-Deoxyguanosine (dG) or 8-OH-dG. P17 in the supernatants or pro-IL-1β in the cell lysate was determined by western blot.

2'-Deoxyguanosine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Mar 31;30(13):4370-4385.e7. [Abstract]

THP-1PMA 167 cells were infected by SFTSV (MOI = 10) for 24 hours in the presence of 2'-Deoxyguanosine (dG) or 8-OH-dG. IL-1β levels in the supernatants were determined by ELISA.
Anal Chem

Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]

2025 May 13;97(18):9827-9835. PMID: 40302637
Talanta

A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]

2024 Jan 15:267:125171. PMID: 37696233
PLoS Genet

A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype. [Abstract]

2026 Jan 23;22(1):e1012013. PMID: 41575937

2'-Deoxyguanosine monohydrate purchased from MedChemExpress. Usage Cited in: PLoS Genet. 2026 Jan 23;22(1):e1012013. [Abstract]

The effect of supplementing OP50-enriched metabolites to HT115 diet on the developmental rate of chca-1 mutant worms.
Each metabolite was added to HT115 and seeded on NGM plates at 20 mM or their saturating concentration (final concentration: 20 mM spermidine, 6 mM thymidine, 20 mM GSSG, 20 mM 2’-deoxyuridine, 6 mM N(1)-acetylspermine, 4 mM 2’-Deoxyguanosine, 6 mM adenosine-2’,3’-cyclic monophosphate, 1 mM 2’-deoxyinosine, 20 mM spermine). Synchronized eggs were seeded on the prepared plates to record developmental rate.
Research Square Preprint

2021 Aug.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (87.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5056 mL

17.5279 mL

35.0557 mL

5 mM

0.7011 mL

3.5056 mL

7.0111 mL

10 mM

0.3506 mL

1.7528 mL

3.5056 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (4.38 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.25 mg/mL (4.38 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ravanat JL, et al. Reaction of singlet oxygen with 2'-deoxyguanosine and DNA. Isolation and characterization of the main oxidation products. Chem Res Toxicol. 1995;8(3):379-388. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5056 mL	17.5279 mL	35.0557 mL	87.6393 mL
	5 mM	0.7011 mL	3.5056 mL	7.0111 mL	17.5279 mL
	10 mM	0.3506 mL	1.7528 mL	3.5056 mL	8.7639 mL
	15 mM	0.2337 mL	1.1685 mL	2.3370 mL	5.8426 mL
	20 mM	0.1753 mL	0.8764 mL	1.7528 mL	4.3820 mL
	25 mM	0.1402 mL	0.7011 mL	1.4022 mL	3.5056 mL
	30 mM	0.1169 mL	0.5843 mL	1.1685 mL	2.9213 mL
	40 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1910 mL
	50 mM	0.0701 mL	0.3506 mL	0.7011 mL	1.7528 mL
	60 mM	0.0584 mL	0.2921 mL	0.5843 mL	1.4607 mL
	80 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL

Bioz

Keywords

2'-Deoxyguanosine monohydrate

6 Cited Publications

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