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Art. -Nr.: HY-145728

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Alicaforsen

(Synonyms: ISIS-2302)

Alicaforsen is an oligonucleotide and immunostimulant targeting human ICAM-1 mRNA. Alicaforsen hybridizes to specific sites to reduce the expression level of ICAM-1. Alicaforsen is applicable to relevant research on psoriasis, rheumatoid arthritis and inflammatory bowel disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 185229-68-9
Molecular Weight:6370.15

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Alicaforsen Chemical Structure

CAS. Nr.: 185229-68-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

Alle Integrin Isoform-spezifische Produkte anzeigen :

In Vivo

Repeated intravenous administration of Alicaforsen (ISIS-2302) (0.8-100 mg/kg; i.v.; every other day; 27 days) to CD-I mice produces dose-dependent, mostly reversible non-specific toxic effects (including immune stimulation, hepatic perturbations, and multiorgan mononuclear cell infiltrates) that are most pronounced at the 100 mg/kg dose level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-I (6-8 weeks old, 20-30 g, male and female)^[1]
Dosage:

0.8 mg/kg; 4 mg/kg; 20 mg/kg; 100 mg/kg
Administration:

i.v.; every other day; 27 days
Result:

Increased incidence of injection-site hematomas at doses >4 mg/kg; observed injection-site hemorrhage, chronic inflammation, and perivasculitis at 20 and 100 mg/kg, with partial reversibility after a recovery period.
Triggered 3- to 4-fold increases in aspartate and alanine aminotransferase, 1.5- to 2-fold increases in total bilirubin and alkaline phosphatase, and reductions in cholesterol (41-48% of control), triglycerides (63-71% of control), and glucose (76-82% of control) at 100 mg/kg; these changes were mostly reversible after recovery, with only slight persistent elevations in alkaline phosphatase and aspartate aminotransferase.
Produced dose-dependent histopathologic changes.

Chemical Information

CAS. Nr. 185229-68-9
Molecular Weight 6370.15
SMILES

[Alicaforsen]
Synonyms

ISIS-2302
Sequence

DNA, d[(R)-P-thio](G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

Verweise

[1]. Henry SP, et al. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice. Antisense Nucleic Acid Drug Dev. 1997;7(5):473-481. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Alicaforsen

Alle Integrin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

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Alicaforsen Related Classifications

HY-145728 Related Classifications