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  4. Alicaforsen sodium

Alicaforsen (ISIS-2302) sodium is an oligonucleotide and immunostimulant targeting human ICAM-1 mRNA. Alicaforsen sodium hybridizes to specific sites to reduce the expression level of ICAM-1. Alicaforsen sodium is applicable to relevant research on psoriasis, rheumatoid arthritis and inflammatory bowel disease.

For research use only. We do not sell to patients.

DNA, d(P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A), sodium salt (1:19)

Alicaforsen sodium Chemical Structure

CAS No. : 331257-52-4

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Alicaforsen sodium Related Antibodies

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Description

Alicaforsen (ISIS-2302) sodium is an oligonucleotide and immunostimulant targeting human ICAM-1 mRNA. Alicaforsen sodium hybridizes to specific sites to reduce the expression level of ICAM-1. Alicaforsen sodium is applicable to relevant research on psoriasis, rheumatoid arthritis and inflammatory bowel disease[1].

In Vivo

Repeated intravenous administration of Alicaforsen (ISIS-2302) (0.8-100 mg/kg; i.v.; every other day; 27 days) to CD-I mice produces dose-dependent, mostly reversible non-specific toxic effects (including immune stimulation, hepatic perturbations, and multiorgan mononuclear cell infiltrates) that are most pronounced at the 100 mg/kg dose level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-I (6-8 weeks old, 20-30 g, male and female)[1]
Dosage: 0.8 mg/kg; 4 mg/kg; 20 mg/kg; 100 mg/kg
Administration: i.v.; every other day; 27 days
Result: Increased incidence of injection-site hematomas at doses >4 mg/kg; observed injection-site hemorrhage, chronic inflammation, and perivasculitis at 20 and 100 mg/kg, with partial reversibility after a recovery period.
Triggered 3- to 4-fold increases in aspartate and alanine aminotransferase, 1.5- to 2-fold increases in total bilirubin and alkaline phosphatase, and reductions in cholesterol (41-48% of control), triglycerides (63-71% of control), and glucose (76-82% of control) at 100 mg/kg; these changes were mostly reversible after recovery, with only slight persistent elevations in alkaline phosphatase and aspartate aminotransferase.
Produced dose-dependent histopathologic changes.
Molecular Weight

6370.15 (free acid)

CAS No.
SMILES

[Alicaforsen (sodium)]
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Alicaforsen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alicaforsen331257-52-4ISIS-2302ISIS2302ISIS 2302IntegrinInhibitorinhibitorinhibit

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