country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-146409

Copy Link Print Information

Antitumor agent-59

Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2409952-04-9
Formel: C₄₃H₃₆F₂N₆O₆
Molecular Weight:770.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Antitumor agent-59 Chemical Structure

CAS. Nr.: 2409952-04-9

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.73 μM Compound: 13b	In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
HCT-116	IC₅₀	0.032 μM Compound: 13b	In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
HUVEC	IC₅₀	0.58 μM Compound: 13b	In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
MCF7	IC₅₀	0.2 μM Compound: 13b	In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]

In Vitro

Antitumor agent-59 (Compound 13b) (72 h) shows antitumor activities with IC₅₀ values of 0.032 ± 0.0071, 0.20 ± 0.020, 0.73 ± 0.12 and 0.58 ± 0.15 μM against HCT116, MCF-7, A549 and HUVEC cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2409952-04-9
Molecular Weight 770.78
Formel C₄₃H₃₆F₂N₆O₆
SMILES

CN1C2=C(C(N3CCC4=C(C13)NC5=CC=C(C=C54)OC(CCCC(OC6=CC=C7NC8=C(C7=C6)CCN9C(C%10=C(N(C89)C)C=CC(F)=C%10)=O)=O)=O)=O)C=C(C=C2)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liang H, et al. Discovery of novel bis-evodiamine derivatives with potent antitumor activity. Bioorg Med Chem. 2022 Jul 1;65:116793. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen