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Art. -Nr.: HY-149829

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Antitumor agent-97

Antitumor agent-97 (compound 42) is an anticancer agent. Antitumor agent-97 can effectively inhibit the proliferation and autophagy of MGC 803 cells, and induce apoptosis. Antitumor agent-97 also enhances ROS accumulation in MGC 803 cells. Antitumor agent-97 can be used in cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2654024-16-3
Formel: C₂₄H₃₄O₃
Molecular Weight:370.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antitumor agent-97 Chemical Structure

CAS. Nr.: 2654024-16-3

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antitumor agent-97 (Compound 42; 0-200 μM; 24 h) inhibits cell viability of MGC 803 cells in a dose-dependent manner, with an IC₅₀ value of 20.921 μM^[1].
Antitumor agent-97 (20 μM; 24 h) decreases cell proliferation of MGC 803 cells^[1].
Antitumor agent-97 (20 μM; 24 h) induces apoptosis and inhibits autophagy in MGC 803 cells^[1].
Antitumor agent-97 (20 μM; 0-24 h) enhances ROS accumulation in MGC 803 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MGC 803 cells
Concentration:

0-200 μM
Incubation Time:

24 h
Result:

Suppressed cell viability (IC₅₀ = 20.921 μM).

Cell Proliferation Assay^[1]

Cell Line:

MGC 803 cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Inhibited cell proliferation.

Western Blot Analysis^[1]

Cell Line:

MGC 803 cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Significantly upregulated the protein expression of LC3B-II and p62 and decreased the protein expression of LC3B-I.
Enhanced the protein expression of cleaved caspase-9 and cleaved caspase-3, and decreased the protein expression of B-cell lymphoma-2 (Bcl-2).

Chemical Information

CAS. Nr. 2654024-16-3
Molecular Weight 370.52
Formel C₂₄H₃₄O₃
SMILES

C[C@@]12[C@](CCC3=CC(C(C)C)=CC=C32)([H])[C@](C)([C@H](CC1)O)COC(C4CC4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mao XD, et al. Synthesis and Bioactivity Evaluation of Nepetaefolin F and Its Analogues. ACS Omega. 2023 Apr 12;8(16):14830-14840. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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