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Art. -Nr.: HY-157460

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BRD4 Inhibitor-29

BRD4 Inhibitor-29 (SQ-17) is a BRD4 inhibitor, with an IC₅₀ of <100 nM. BRD4 Inhibitor-29 shows antiproliferative effect against prostate cancer cells.

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CAS. Nr.: 902563-50-2
Formel: C₂₁H₂₈N₂O₃
Molecular Weight:356.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BRD4 Inhibitor-29 Chemical Structure

CAS. Nr.: 902563-50-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BRD4 Inhibitor-29 (SQ-17) is a BRD4 inhibitor, with an IC₅₀ of <100 nM. BRD4 Inhibitor-29 shows antiproliferative effect against prostate cancer cells^[1].

IC₅₀ & Target^[1]

BRD4

<100 nM nM (IC₅₀)

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Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	17.48 μM Compound: SQ-17	Cytotoxicity against human androgen-independent/androgen-responsive 22Rv1 cells assessed as cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human androgen-independent/androgen-responsive 22Rv1 cells assessed as cell viability incubated for 96 hrs by MTT assay	[PMID: 38153295]
DU-145	IC₅₀	87.12 μM Compound: SQ-17	Cytotoxicity against human DU-145 cells assessed as cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human DU-145 cells assessed as cell viability incubated for 96 hrs by MTT assay	[PMID: 38153295]
LNCaP	IC₅₀	4.03 μM Compound: SQ-17	Cytotoxicity against human AR-dependent LNCaP cells assessed as cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human AR-dependent LNCaP cells assessed as cell viability incubated for 96 hrs by MTT assay	[PMID: 38153295]
PC-3	IC₅₀	28.59 μM Compound: SQ-17	Cytotoxicity against human PC-3 cells assessed as cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as cell viability incubated for 96 hrs by MTT assay	[PMID: 38153295]

Chemical Information

CAS. Nr. 902563-50-2
Molecular Weight 356.46
Formel C₂₁H₂₈N₂O₃
SMILES

O=C(NC1CCCCCC1)CCCOC2=CC(N(C)C3=CC=CC=C32)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Haiyang Zhong, et al. Discovery of Novel Inhibitors of BRD4 for Treating Prostate Cancer: A Comprehensive Case Study for Considering Water Networks in Virtual Screening and Drug Design. J Med Chem. 2024 Jan 11;67(1):138-151. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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BRD4 Inhibitor-29

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Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BRD4 Inhibitor-29 Related Classifications

HY-157460 Related Classifications