Fkbp1b - FK506 binding protein 1b Gene

Also Known as 12.6kDa; FKBP12.6; calstabin2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14226

Summary

Enables FK506 binding activity; peptidyl-prolyl cis-trans isomerase activity; and transmembrane transporter binding activity. Involved in negative regulation of heart rate; regulation of cytosolic calcium ion concentration; and regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including Insulin secretion; negative regulation of Insulin secretion involved in cellular response to glucose stimulus; and neuronal action potential propagation. Located in sarcoplasmic reticulum membrane. Part of Calcium Channel complex. Is expressed in nervous system and testis. Used to study catecholaminergic polymorphic ventricular tachycardia. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp1b Products (4)

mRNA Protein Name
NM_001378816.1 NP_001365745.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 2
NM_001378817.1 NP_001365746.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 3
NM_001378818.1 NP_001365747.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 4
NM_016863.4 NP_058559.3 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables FK506 binding IDA
IDA: Inferred from direct assay
14592808 MGI
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
16481613 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14592808 MGI
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
16213210 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
14605212 MGI
involved in calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
22087651 MGI
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
18466757 MGI
acts upstream of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19805579 MGI
involved in negative regulation of heart rate IMP
IMP: Inferred from mutant phenotype
12837242 MGI
acts upstream of or within negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19805579 MGI
acts upstream of or within neuronal action potential propagation IMP
IMP: Inferred from mutant phenotype
14605212 MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
19805579 MGI
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
IMP: Inferred from mutant phenotype
12837242 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
16672364 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
14592808 MGI
involved in regulation of ryanodine-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
12837242 MGI
acts upstream of or within release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
15024040 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
18466757 MGI
acts upstream of or within smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
14592808 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
16213210 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
19578067 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
14592808 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP1B

  • 12.6 kDa FK506-binding protein

  • 12.6 kDa FKBP

  • FK506-binding protein 12.6

  • FK506-binding protein 1B

  • FKBP-12.6

  • FKBP-1B

  • PPIase FKBP1B

  • immunophilin FKBP12.6

  • rotamase

Fkbp1b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Fkbp1b Q9Z2I2 Ryr2 Mus musculus E9Q401
Anti Bait CoIP
22939628
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04961 FKBP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp1b NCBI NCBI:2281