Erfe - erythroferrone Gene

Also Known as Fam132b; myonectin; 4832406C22

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227358

Summary

Enables hormone activity and identical protein binding activity. Involved in cellular iron ion homeostasis. Acts upstream of or within positive regulation of fatty acid transport and regulation of fatty acid metabolic process. Located in extracellular space. Orthologous to human ERFE (erythroferrone). [provided by Alliance of Genome Resources, Apr 2022]

Erfe Products (1)

mRNA Protein Name
NM_173395.2 NP_775571.2 erythroferrone precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables hormone activity IDA
IDA: Inferred from direct assay
24880340 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22351773 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
30097509 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of establishment of localization in cell IDA
IDA: Inferred from direct assay
22351773 MGI
acts upstream of fatty acid transport IDA
IDA: Inferred from direct assay
22351773 MGI
involved in intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
24880340 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
30566056 MGI
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
24187137 MGI
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
34002695 MGI
acts upstream of negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
34002695 MGI
acts upstream of or within positive regulation of fatty acid transport IDA
IDA: Inferred from direct assay
22351773 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
30566056 MGI
acts upstream of or within regulation of fatty acid metabolic process IDA
IDA: Inferred from direct assay
22351773 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular region IDA
IDA: Inferred from direct assay
24880340 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
22351773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

erythroferrone

  • complement C1q tumor necrosis factor-related protein 15

  • family with sequence similarity 132, member B

  • protein FAM132B

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P99590A Sotatercept (mIgG2a) Inhibitor 99.93% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04489 ERFE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16922 Erfe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23365 Erfe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erfe NCBI NCBI:151176